Many estuarine researchers have chosen the Columbia River Estuary as their focus—for good reason! The Columbia River Estuary is a complex landscape that balances intricate environmental systems while supporting services like recreation, navigation, flood control, and commerce. Several research institutions are hard at work uncovering how the estuary functions from many perspectives—sediment, hydrology, fish ecology, vegetation, and more. Our multidisciplinary research community is investigating all angles to better understand this complex system and inform program management and restoration approaches to optimize restoration effectiveness.